It's all about looking at potential and banking on injuries/underperforming starters and younger breakout candidates. Here's a mock I just did, drafting from the 7th slot (took Julio 1st):
Thoughts:
Little debate that my top-4 WRs are stacked. Finished off the group with 2 high upside guys later in the draft. In a 2 or 3 WR and 1 Flex league, I should win my WR and Flex matchups mostly every week.
In round 5 the WR pool was pretty depleted so turned my attention to the RBs. I felt that the guys I was targeting were gonna last until my next picks (and they did), which is why I went with Kelce. He should be able to win me the TE matchup most weeks as well.
The first two RBs I grabbed are potential PPR mavens. Vereen and Woodhead are both only a season removed from top-15 PPR RB finishes.
My next 4 RBs are all guys in uncertain backfield situations. Cleveland's backfield is a mess, so who's to say Duke Johnson can't win that job? Same with David Cobb. We saw how Sankey fared last year, so I can easily imagine a scenario of Cobb winning that job whether it's in the preseason or during the regular season. The Arizona backfield doesn't have alot of clarity either. David Johnson is a similar athlete to the fragile Andre Ellington. He's one injury away from stepping in. Doug Martin has been a disaster in TB. Sims has a good shot at taking over that backfield. Or even just playing a 3rd down role he could become a PPR asset. The Bucs figure to be playing from behind alot this season.
With my WRs locking up my Flex spot weekly, I only need to "hit" on two of my RBs. And with the weekly domination of the WR and Flex spots, two guys in the RB20 range will be more than adequate.