the short answer is no, you should be able to shoot in either aperture priority or shutter/time priority (not sure how these modes are displayed on your specific camera) and auto iso, which will lessen the amount of adjustments you will have to make...
the long answer, if you really want to get familiar with shooting on a DSLR with an optical viewfinder (mirrorless cameras don't have this particular issue because of the electronic viewfinder that displays what the image sensor will capture in real-time) is yes you will often have to adjust (even in some of the aforementioned 'auto' modes above) to the different photographic circumstances that come with changing availability of light, the amount of depth of field you want, and the amount of motion you want in the image. you will have to know your camera enough to figure out the relationship between what you see thru the optical viewfinder and the what the camera is seeing...so there will be, as a matter of necessity, much trial and error