Some interesting information about how different vaccines/boosters/infections provide (or not) protection against BA.5, and the varying levels of antibodies from 2 or 3 doses of the same or different vaccines. He also explains why all the vaccines target the spike protein and whether the variant mutations to spike make the original vaccines ineffective.
TL;DR - Prior infection does not provide a reliable level of immunity because inoculation dose is different for every infection compared to a standard vaccine dose that provides a stable antibody & B/T cell response in the majority of individuals. 2 doses (or 1 J&J
) is not enough and you need a 3rd dose ASAP if you haven't already. The OG recipe is still damn good at preventing the most severe outcomes. Spike is an effective target because antibodies cover the exterior of the virus and prevent it from entering cells, and despite the number of mutations to the spike of any particular variant, there are still enough similarities that the immune system will provide a high degree of protection against severe outcomes.