I had an RMR mounted on an M&P 45 compact, and shot it extensively for about 8 months, and 5000 rounds. I could not use the rear sight, and eventually had a rear sight installed in front of the optic and replaced the stock sights with suppressor height sights. I had them co witnessed with the dot and it makes life easier.
You'll probably struggle with sight alignment and searching for the dot with the non co witnessed sights, as there will be multiple points of reference in your view. With the co witnessed sights, it's much more natural as you instinctively bring the gun up and begin aligning the sights via muscle memory. Once the gun is up and you have your sights aligned, then the dot will be on target and all you have to do is focus on is trigger press and ''wobble"/keeping the sights steady.
If you do go with that setup, please let us know how it works out. Really curious about the Vortex optics on a slide mounted pistol.