If you're in the "Montrose Area," then you're not in a gay area anymore. The gays are isolated to Montrose and Fairview intersection and surrounding areas down Fairview.
Montrose further north becomes Washington/Heights (not gay), and Montrose further south becomes Westheimer, Museum, etc. (also, not gay). The Pride Parade was in that area, but the majority of gay places have been closed, moved, or otherwise ousted.
5th Amendment hasn't been worth going to for nearly a year, now. I haven't been clubbing like I used to because of law school, but when I do go out it's usually to St. Genevieve, Hearsay, or Hughe's Hangar (lounges rather than clubs). Most of Washington has gotten pretty hood, now. Almost all of those clubs have ran their course and are nothing like what they once were.
Roak and Red Door are the last clubs I've gone to that still have a decent layout and atmosphere. I think Red Door has one of the best designs of all the clubs in the city--compared to a place like 5th Amendment which is just a room with a bar and some LED lights. Drake has a good layout, but after the original owners sold it, the place changed drastically in re the crowd. If you want to go to good looking, chill places with good looking people, St. Genevieve and Hughe's Hangar are probably the best places IMO. Roak will have some good looking women, but I've seen people have a lot of issues with the door guys there. Nouveau, Hearsay, State Bar, and RDG are some of the better looking bars in the city but they don't have door people to narrow their crowd down so you can get a broader spectrum of people.
If you're not trying to go to as snobby a place and get a good deal on food and drinks, I'd highly recommend Royal Oak.
z burgers for $9, bottles of wine/champagne for $11, and $7 mimosa pitchers on Sundays. Good layout, one of the best patios in Houston, and usually lots of good looking people, too.