Yeah, I'm a pretty serious runner, about 200km a month, and I switched over to Nike's a few years back with no issue.
I put in over 800km on my Lunar Flyknit 2s and though the Lunarlon has obviously lost its plushness, they're still really comfy.
If you're casual about running, Lunarlon are great for shorter distances like 5-10km runs. When I do more serious outings I switch over to Zoom Elite 8s, which seems like a popular choice for competitive Nike-sponsored athletes--also on crazy clearance pretty much all over the place now. Grabbed a pair off NDC for $80 this past winter. They're way, way more firm, but stable as hell, and have a forefoot zoom--which you can't really feel.
Bottom line though is that barring crazy foot issues, you can run in absolutely anything if you know how to maintain yourself.